What one show to see? Wife first time in Vegas..

For Cirque - O or KA. La Reve is a similar and also terrific.
"Vegas" type, Jubilee
Music- Jersey Boys or Human Nature.
"broadway type" - Phantom
Matinee- Mac King (comedy) or Menopause (comic musical)

One Choice?- Phantom

I would suggest trying to squeeze in a Matinee as well as an evening show.

Note that you can get discounts on ALL of these but O at tix 4 tonite regularly.

Love

If Human Nature is in town, definitely worth seeing if you like music.

Yeah, I'd have to agree with tennis_bum about HUMAN NATURE.
If you're a fan of MOTOWN, it's really entertaining. I suggest paying the
rack rate for a guaranteed BOOTH 307,306, 305...SEATS 1 and 2.
MUSIC is the great entertainer...
Call the IP for tics 1.888.777.7664

As you've seen, without giving any ideas on your part, you've got lots
of suggestions. Some you'll like, some ya won't.

Love or Absinthe

Mystere & Mac King, since you said Celine was out.

Jersey Boys or LOVE.