Cotto is a converted southpaw. Meaning he is left handed but leads with his left hand. His right has always been mostly useless. So Mayweather really only has to really worry about the one hand for the most part. It really depends on Mayweather and Cotto's mentality and how his face holds up. Mayweather hasn't really shown it much, but he does has good power. He'll have a 5 inch reach advantage as well. This isn't much different for what I've been saying for a few years, Mayweather wins this one probably via decision or late stoppage, and he'll put an ass whooping on Pacquiao if they ever meet. Cotto doesn't have a lot of quit in him but his face has been know to get really cut up. Like I said, If you like some even games or some other fights add Mayweather to a parlay, he'll win this fight and it won't be close. I wish he'd have fought Pacquiao last year, fight would have opened close to even and I would have bet ever dollar they'd let me on Mayweather.