I agree with Mr. Bowling - since the Saints are one of the better teams, you'll want to pick them at some point, and now looks to be the time.
There are some who advocate staying away from the highest-lined games (because that's what everyone else chooses, presumably), but I disagree with that philosophy. For one thing, it's riskier. Secondly, you'd be surprised how many players DON'T pick those games, which is an advantage to you. I remember being in one of these several years ago, and there was one game that stuck out like a sore thumb (the only DD line on the card), yet only something like 82% of the field picked it. Of course, once you get deeper in the season you may not have that kind of flexibility.
If you have access to who's picking which games in real time, use this information to full advantage, and make your selection as late as possible!
Hope this helps, and good luck!
