Taking big favorites now a good thing?

Taking big favorites now a good thing? In prior years, when I'd see a team favored by more than 25 points, I'd just leave it alone. After last year's blueprint, displayed by Oklahoma, is it much safer to take large favorites ATS? Oklahoma proved that blowing out opponents by the largest of margins faired well in the computer polling. If the top teams in the country follow this year, I'd think it would be much more common seeing 40-70 point victories with the piling on of points in the 4th.
We favor favorites until November.