The only time when you have to deal with high elevations is when you go through Tonopah, which lies at the top of a pass that's over 6,000 feet. That's the only place I've ever encountered any significant snow. That said, if a storm comes through while you're there, the stretch from Goldfield to Hawthorne can be pretty brutal.
The worst aspects of the trip are 1) God help you if you break down, it may take all day to get a tow truck to you and you'll be taken to the cleaners when you finally get repairs done. Just imagine spending three nights at the Clown Motel in Tonopah waiting for your car parts to arrive from Reno, and then getting hit with a $1500 bill to replace your water pump or alternator. Because really, where else are ya gonna go? 2) Pretty much the entire length of the Whorehouse Highway is one huge speed trap. County Mounties lurk just outside the city limits--which are often WAAAAAY out in the desert, miles from the town itself--and pounce when you happen on that sudden SPEED LIMIT 35 sign and before you can even react, the red lights come on behind you. Most of the shit little towns on 95 rely on waylaying passersby for a significant portion of their income.
For the above reasons, I'd rather be stripped naked, smeared with honey, and buried neck-deep in an anthill than ever, ever, ever drive the Whorehouse Highway again.