Here is a bet suggestion....
Take the four #1 seeds as a 4 team parlay on the money line for the 1st round game.
A #1 has not lost a first round game since the NCAA went to a 64 team format. IMHO this is a no brainer. The odds won't be great, but even a 2-1 payout could be very profitable.....AND IT HAS NEVER LOST!
Best performances by #16 seeds
No team as a #16 seed has ever defeated a #1 seed since the field was expanded to 64 or more teams, though on four occasions, a #16 seed has come within 4 or fewer points of winning:
While ultimately Murray State lost to Michigan State by 4 points in 1990, they were the only #16 team to ever take a game into overtime.
East Tennessee State lost to Oklahoma in 1989 (1 point, 72–71)
Princeton lost to Georgetown in 1989 (1 point, 50–49)
Western Carolina lost to Purdue in 1996 (2 points, 73–71)